AIM: To investigate the effects of substance P on the human eosinophil adhesion to endothelial cells and its mechanism. 目的:探讨P物质对嗜酸性粒细胞粘附功能的调节作用及机制。
Methods: The counting of peripheral blood eosinophil cells ( PBEC) was performed by the routine method. Sandwich ELISA was used to measure the level of IL-18 and IL-12 in the serum of the patients and health controls. 方法:按常规方法作外周血嗜酸性粒细胞(PBEC)绝对计数,采用酶联免疫吸附法(ELISA)测定AD患者和健康对照血清IL-18和IL-12的水平。
Effect of eosinophil major basic protein on histamine release from nasal epithelial mast cells 嗜酸粒细胞主体碱性蛋白对鼻粘膜上皮肥大细胞组胺释放的影响
Inflammatory cell number in BALF, eosinophil infiltration in the lung tissue with HE stain and goblet cells in the bronchial mucous membrane with PAS stain were examined. Dexamethasone was employed to validate the model. 检测AB-PAS染色的支气管上皮杯状细胞数目,HE染色的肺组织嗜酸性粒细胞浸润和支气管灌洗液中的炎症细胞数目,并用已知有效药物和未知受试药物验证此模型。
Conclusion ECP is an important chemokine secreted by activated eosinophil cells. 结论ECP是嗜酸粒细胞活化后脱颗粒释放的主要炎性介质,是反映支气管哮喘气道炎症发生发展的重要指标之一。
Eosinophil induced in vivo T cell proliferation was antigen specific, and the responding T cells were limited to CD4+ cells. 此外,EOS呈递抗原所引起的T细胞增殖反应具抗原特异性,出现增殖反应的T细胞仅限于CD+4细胞。
Histopathology showed hyperkeratosis accompanied by focal parakeratosis, vacuolar degeneration of basal layer and superficial dermal bandlike infiltration composed of lymphocytes, and also eosinophil and plasma cells. 组织病理改变主要为角化过度伴灶状角化不全,基底层液化变性,真皮浅层可见淋巴细胞大致呈带状分布,并可见嗜酸性粒细胞和浆细胞浸润。
Single cell suspension was prepared from paratracheal lymph nodes of mice receiving antigen exposed eosinophil instillation, and flow cytometry was used to determine proliferation response of T cells and to identify the subset of responding T cells. 将接受气管EOS注入小鼠的气管旁淋巴结取出后制备单细胞悬液,以流式细胞仪检测其中T细胞的增殖反应并鉴定增殖T细胞的亚群。
Allergic asthma is a chronic airway inflammation with excess express of IgE, infiltration of eosinophil and mast cells, airway hyperreactivity and remodeling. 变应性哮喘是以IgE过量合成、嗜酸性粒细胞和肥大细胞浸润、气道高反应性及气道重塑为主要特征的慢性气道炎症。